A Scalable Synthesis of Chiral Modular Phosphine–Phosphite Ligands

Abstract

The outstanding usefulness of phenol-derived chiral phosphine–phosphite ligands has recently been shown in a number of transition-metal-catalyzed C–C bond-forming reactions. This is exemplified by the synthesis of five new ligands in an optimized procedure that can be reliably performed on a multigram scale.

Key words

Chiral P,P-ligands - enantioselective catalysis - bromine–lithium exchange - synthetic methods - asymmetric 1,4-addition

• References

• 1 M. Dindaroğlu and A. Falk contributed equally to this work.
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