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Synthesis 2012; 44(18): 2959-2963
DOI: 10.1055/s-0032-1316749
DOI: 10.1055/s-0032-1316749
paper
Synthesis of Azabipyridine and Azaterpyridine Building Blocks for Multitopic Binding
Further Information
Publication History
Received: 14 May 2012
Accepted after revision: 23 June 2012
Publication Date:
03 August 2012 (online)
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Abstract
We describe the synthesis of four bromo-substituted azabipyridines and two bromo-substituted azaterpyridines through a series of palladium-catalyzed cross-coupling reactions. Both the azabipyridine and azaterpyridine heterocycles contain two orthogonal binding motifs, the value of which has been demonstrated recently in a nanomechanical switch for triggering organocatalysis. The bromo functionality allows heterocyclic ligands to be attached to larger frameworks.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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For some selected reviews, see: