Synlett 2012; 23(13): 1990-1994
DOI: 10.1055/s-0032-1316582
letter
© Georg Thieme Verlag Stuttgart · New York

Design, Synthesis and Use of Novel 3,3′-Disubstituted 2,2′-Bipyridine-Based Chiral Ligands: Asymmetric Catalysis in Direct Aldol Reactions

Authors

  • Hong-Wu Zhao*

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
  • Hai-Long Li

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
  • Yuan-Yuan Yue

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
  • Xiao Qin

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
  • Zhi-Hui Sheng

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
  • Jin Cui

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
  • Shi Su

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
  • Xiu-Qing Song

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
  • Hong Yan

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
  • Ru-Gang Zhong

    College of Life Science and Bioengineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, P. R. of China, Fax: +86(10)67396200   eMail: hwzhao@bjut.edu.cn
Weitere Informationen

Publikationsverlauf

Received: 12. Mai 2012

Accepted after revision: 29. Mai 2012

Publikationsdatum:
23. Juli 2012 (online)


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Abstract

A wide range of chiral ligands based on the 2,2′-bipyridine scaffold were designed and synthesized. In complexation with metal Lewis acids, the reactivity and stereoselectivity of the prepared chiral ligands were examined in asymmetric catalytic direct aldol reactions, thus providing the desired products with high stereo­selectivities.

Supporting Information