Synlett 2012; 23(14): 2129-2131
DOI: 10.1055/s-0032-1316580
letter
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of (+)-Cryptocaryanone A

Bingbin Zhang
a   State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Fax: +86(931)8912582   Email: shexg@lzu.edu.cn   Email: xiexg@lzu.edu.cn
,
Zhen Yang
a   State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Fax: +86(931)8912582   Email: shexg@lzu.edu.cn   Email: xiexg@lzu.edu.cn
,
Juan Yang
a   State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Fax: +86(931)8912582   Email: shexg@lzu.edu.cn   Email: xiexg@lzu.edu.cn
,
Gaoyuan Zhao
a   State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Fax: +86(931)8912582   Email: shexg@lzu.edu.cn   Email: xiexg@lzu.edu.cn
,
Bin Ma
a   State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Fax: +86(931)8912582   Email: shexg@lzu.edu.cn   Email: xiexg@lzu.edu.cn
,
Xingang Xie*
a   State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Fax: +86(931)8912582   Email: shexg@lzu.edu.cn   Email: xiexg@lzu.edu.cn
,
Xuegong She*
a   State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Fax: +86(931)8912582   Email: shexg@lzu.edu.cn   Email: xiexg@lzu.edu.cn
b   State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. of China
› Author Affiliations
Further Information

Publication History

Received: 07 May 2012

Accepted after revision: 27 May 2012

Publication Date:
04 July 2012 (online)


Preview

Abstract

The first total synthesis of (+)-cryptocaryanone A is described. The synthesis features a Mukaiyama aldol reaction, one-pot saponification/lactonization sequences, and TsOH-assisted dihydropyrone formation as key steps.

Supporting Information