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Synthesis 2012; 44(16): 2614-2622
DOI: 10.1055/s-0032-1316564
DOI: 10.1055/s-0032-1316564
paper
Simple Ultrasound-Assisted Synthesis of 3,4-Dihydropyrimidin-2(1H)-one and 3,4-Dihydropyrimidine-2(1H)-thione-Fused Steroidal Derivatives by a Three-Component Reaction
Further Information
Publication History
Received: 26 April 2012
Accepted after revision: 30 May 2012
Publication Date:
13 July 2012 (online)
Abstract
Compounds containing fused 3,4-dihydropyrimidin-2(1H)-one or 3,4-dihydropyrimidine-2(1H)-thione moieties were prepared by three-component reactions of a steroidal or nonsteroidal ketone, an alkyl or aryl aldehyde, and urea or thiourea in the presence of sodium ethoxide. The products were isolated in good yields after short reaction times under mild conditions.
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