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Synlett 2012; 23(19): 2763-2767
DOI: 10.1055/s-0032-1316556
DOI: 10.1055/s-0032-1316556
cluster
Ruthenium-Catalyzed Direct ortho-Alkynylation of Arenes with Chelation Assistance
Further Information
Publication History
Received: 18 April 2012
Accepted after revision: 28 May 2012
Publication Date:
16 July 2012 (online)
Abstract
The ruthenium-catalyzed direct alkynylation of arenes with the chelation assistance of nitrogen-containing heterocycles including pyridine, pyrimidine, pyrazole, and imidazole are described. The alkynylation is successful even in the presence of an acidic N–H bond. Broad compatibility with functional groups is observed under catalytic conditions. The obtained alkynylated products could serve as precursors for polycyclic heteroarenes.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
-
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Selected reviews on catalytic C–H bond-functionalization reactions:
Catalytic alkynylation using metals other than shown above: Gallium:
For heterogeneous catalysis, see:
Selected examples of ruthenium-catalyzed C–H functionalization: For arylation, see:
For alkenylation, see:
For alkylation, see:
For other reactions, see: