Towards an Efficient Preparation of Hydromorphone

René Csuk; Galina Vasileva; Alexander Barthel

doi:10.1055/s-0031-1291151

Synthesis, Table of Contents

Synthesis 2012; 44(18): 2840-2842
DOI: 10.1055/s-0031-1291151

practical synthetic procedures

Towards an Efficient Preparation of Hydromorphone

René Csuk*

Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Kurt-Mothes-Straße 2, 06120 Halle (Saale), Germany, Fax: +49(345)5527030 Email: rene.csuk@chemie.uni-halle.de

,

Galina Vasileva

Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Kurt-Mothes-Straße 2, 06120 Halle (Saale), Germany, Fax: +49(345)5527030 Email: rene.csuk@chemie.uni-halle.de

,

Alexander Barthel

Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Kurt-Mothes-Straße 2, 06120 Halle (Saale), Germany, Fax: +49(345)5527030 Email: rene.csuk@chemie.uni-halle.de

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Abstract

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Dedicated to Prof. Dr. Wolf-Dieter Rudorf on the occasion of his 70^th birthday. Ad multos annos!

Abstract

Dihydromorphone was prepared from morphine in high yield, excellent purity, and low residual metal content. The key steps used palladium on porous glass and a modified Oppenauer oxidation, or Wilkinson’s catalyst.

Key words

alkaloids - catalysis - oxidation - reduction - supported catalysis

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References

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