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Synthesis 2012; 44(13): 2005-2012
DOI: 10.1055/s-0031-1291145
DOI: 10.1055/s-0031-1291145
paper
Fluorescence Labeling of Amino Acids and Peptides with 7-Aminocoumarins
Further Information
Publication History
Received: 13 March 2012
Accepted after revision: 18 April 2012
Publication Date:
05 June 2012 (online)
Abstract
Pechmann condensation is a straightforward protocol for the synthesis of alkynyl- and azido-substituted 7-(dialkylamino)coumarins, which can be coupled to amino acid and peptide derivatives by copper-catalyzed [3+2]-cycloaddition (click reaction) in high yield. This allows the introduction of these efficient fluorescence labels into biologically relevant molecules.
Key words
amino acids - click chemistry - cycloaddition - coumarins - fluorescence labeling - peptidesSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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