Regio- and Stereoselective Multicomponent Coupling Reaction of Alkynes and Dimethylzinc Involving Allylnickelacycles

Abstract

Nickel catalyzes the multicomponent coupling reaction of vinyl epoxides, alkynes, and dimethylzinc to provide hepta-2,5-dienyl alcohols as a mixture of E- and Z-isomers in high yields. Vinylcyclopropane participates in a similar multicomponent coupling reaction to afford dimethyl α-(hepta-2,5-dienyl)malonates with excellent E-stereoselectivity.

Key words

nickel - multicomponent coupling - alkyne - dimethylzinc - vinyl epoxide - cyclopropane

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