A Novel and Highly Regioselective Route to Construct Methylthio-Substituted Pyridazines from Aryl Methyl Ketones at Room Temperature

Abstract

A novel and highly regioselective two-step homocoupling/cyclization procedure from easily available aryl methyl ketones and hydrazine hydrate was developed for the synthesis of methylthio-substituted pyridazines at room temperature. The method has remarkable advantages owing to the simple substrates, mild reaction conditions, ease of manipulation, good yields and high ­regioselectivity.

Key words

regioselectivity - homocoupling/cyclization - aryl methyl ketones - hydrazine hydrate - methylthio-substituted pyridazine

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