Synthesis, Antibacterial Activity and Cytotoxicity of Novel Janus Peptide 
Dendrimers

Junzhu Pan; Li Guo; Liang Ouyang; Dongqin Yin; Yi Zhao

doi:10.1055/s-0031-1290403

Synlett, Table of Contents

Synlett 2012; 23(13): 1937-1940
DOI: 10.1055/s-0031-1290403

letter

Synthesis, Antibacterial Activity and Cytotoxicity of Novel Janus Peptide Dendrimers

Junzhu Pan

^aKey Laboratory of Drug Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. of China, Fax: +86(28)85502609 Email: rosaguoli2000@yahoo.com.cn

,

Li Guo*

^aKey Laboratory of Drug Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. of China, Fax: +86(28)85502609 Email: rosaguoli2000@yahoo.com.cn

,

Liang Ouyang

^bState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, P. R. of China

,

Dongqin Yin

^cLaboratory of Stem Cell Biology, West China Hospital West China Medical School, Sichuan University, Chengdu 610041, P. R. of China

,

Yi Zhao

^aKey Laboratory of Drug Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. of China, Fax: +86(28)85502609 Email: rosaguoli2000@yahoo.com.cn

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Abstract

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Abstract

In an attempt to find new antibacterial agents, a series of well-defined Janus peptide dendrimers, which feature multiple anionic groups and amphiphilic structure, were synthesized and characterized in detail. The antibacterial activities of all the synthesized dendrimers were tested and screened by using the two-fold serial dilution method. Several compounds showed activity against E. coli, S. aureus, methicillin-resistant S. aureus, and E. faecalis. Further cytotoxicity assays showed that the antibacterial dendrimers were nontoxic against HEK293.

Key words

Janus dendrimer - peptide dendrimer - amphiphilic - antibiotics - antibacterial activity

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References

References and Notes

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20 Methods for antibacterial and toxicity experiments are given in the Supporting Information (see S2 for details)
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Supplementary Material

Supporting Information