Synthesis 2012; 44(15): 2413-2423
DOI: 10.1055/s-0031-1290384
paper
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Cross-Coupling of O-Alkyl Hydroxamates with Aryl Iodides

Authors

  • Tatyana Kukosha

    Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga 1006, Latvia, Fax: +37167550338   Email: martins@osi.lv
  • Nadezhda Trufilkina

    Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga 1006, Latvia, Fax: +37167550338   Email: martins@osi.lv
  • Sergey Belyakov

    Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga 1006, Latvia, Fax: +37167550338   Email: martins@osi.lv
  • Martins Katkevics*

    Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga 1006, Latvia, Fax: +37167550338   Email: martins@osi.lv
Further Information

Publication History

Received: 28 March 2012

Accepted after revision: 09 May 2012

Publication Date:
19 June 2012 (online)


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Abstract

N-Aryl-O-alkylhydroxamic acid derivatives were prepared by copper-catalyzed cross-coupling of hydroxamates with aryl iodides. The reaction conditions are compatible with standard hydroxy-protecting groups on the hydroxylamine moiety and are applicable to a broad range of coupling partners.

Supporting Information