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Synlett 2012(1): 57-61  
DOI: 10.1055/s-0031-1289875
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© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Intramolecular Hydroamination of N-Alkenyl Ureas Catalyzed by tropos BIPHEP-Gold(I) Complexes with Au-Au Interaction

Masafumi Kojima, Koichi Mikami*
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8550, Japan
Fax: +81(3)57342776; e-Mail: mikami.k.ab@m.titech.ac.jp;
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Publication History

Received 2 October 2011
Publication Date:
11 November 2011 (online)

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Enantioselective Intramolecular Hydroamination of N-Alkenyl Ureas Catalyzed by tropos BIPHEP-Gold(I) Complexes with Au-Au InteractionSynlett 2012; 2012(01): e1-e1
DOI: 10.1055/s-0031-1290122

Abstract

Dinuclear gold complexes significantly accelerate intramolecular hydroamination of N-alkenyl ureas via proximal and bimetallic activation of alkene and urea. Tropos BIPHEP-gold complexes having Au-Au interaction affords higher enantioselectivity than the BINAP-gold counterparts without Au-Au interaction.

Key words

gold - asymmetric catalysis - hydroamination - alkenes - bimetallic activation

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