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Synthesis 2012(6): 927-933  
DOI: 10.1055/s-0031-1289692
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Iodine-Mediated Intramolecular Oxidative Cyclization of 2-(Styrylthio)anilines: Synthesis of 2-Substituted Benzothiazoles

Dong-Yun Zhaoa, Xiao-Kang Guoa, Jin-Heng Li*b, Ri-Yuan Tang*a
a College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China
Fax: +86(577)86689615; e-Mail: try@wzu.edu.cn;
b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China
e-Mail: jhli@hnu.edu.cn;
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Publication History

Received 23 November 2011
Publication Date:
06 February 2012 (online)

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Abstract

A novel metal-free iodine-mediated intramolecular oxidative cyclization protocol is presented, which allows for the preparation of various 2-substituted benzothiazoles.

Key words

iodine - oxidation - cyclization - 2-(styrylthio)aniline - benzothiazole

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