Multicomponent Synthesis of
New Primaquine Thiazolidinone Derivatives

Patrícia D. Neuenfeldt; Bruna B. Drawanz; Anna Caroline C. Aguiar; Flávio Figueiredo Jr.; Antoniana U. Krettli; Wilson Cunico

doi:10.1055/s-0031-1289580

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Synthesis 2011(23): 3866-3870
DOI: 10.1055/s-0031-1289580

PAPER

Multicomponent Synthesis of New Primaquine Thiazolidinone Derivatives

Patrícia D. Neuenfeldt^a, Bruna B. Drawanz^a, Anna Caroline C. Aguiar^b,c, Flávio Figueiredo Jr.^b, Antoniana U. Krettli^b,c, Wilson Cunico*^a
^a Núcleo de Química Aplicada, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, UFPel, Campus Universitário s/no, 96010-900, Pelotas, RS, Brazil
Fax: +55(53)32757454; e-Mail: wjcunico@yahoo.com.br;
^b Centro de Pesquisas René Rachou-Fiocruz, Laboratório de Malária, Av. Augusto de Lima 1715, 30190-002 Belo Horizonte, MG, Brazil
^c Universidade Federal de Minas Gerais, Programa de Pós Graduação em Medicina Molecular, Faculdade de Medicina, Av. Alfredo Balena, 30130-100 Belo Horizonte, MG, Brazil

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Publication History

Received 3 September 2011
Publication Date:
27 October 2011 (online)

Abstract
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Abstract

Primaquine thiazolidinone derivatives, potentially useful as antimalarial agents, were synthesized in good yields by multicomponent reactions of primaquine diphosphate, mercaptoacetic acid, and an optionally substituted benzaldehyde or cyclohexanone for two to four hours. All the products were characterized by ^¹H and ^¹³C NMR spectroscopy and by LC-MS.

Key words

heterocycles - multicomponent reactions - cyclocondensations - antimalarials

References

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