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Synthesis 2011(22): 3692-3696  
DOI: 10.1055/s-0031-1289576
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Coumarins and Neoflavones through Zinc Chloride Catalyzed Hydroarylation of Acetylenic Esters with Phenols

Raquel A. C. Leão, Paula de F. de Moraes, Marcella C. B. C. Pedro, Paulo R. R. Costa*
Laboratório de Química Bioorgânica (LQB), Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Bloco H, Ilha da Cidade Universitária, 21941-590, Rio de Janeiro, RJ, Brazil
Fax: +55(21)25626793; e-Mail: prrcosta2011@gmail.com;
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Publication History

Received 25 July 2011
Publication Date:
27 October 2011 (online)

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Abstract

Acetylenic esters react with oxygenated phenols under solvent-free conditions in the presence of only 5 mol% of zinc chloride as a catalyst to give coumarins and neoflavones in reasonable-to-good yields.

Key words

phenols - catalysis - arylations - heterocycles - alkynes - esters

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