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Synfacts 2011(12): 1372-1372  
DOI: 10.1055/s-0031-1289421
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Oxidative Amidation of Alcohols with Amines Catalyzed by Au/DNA

Contributor(s): Yasuhiro Uozumi, Aya Tazawa
Y. Wang, D. Zhu, L. Tang, S. Wang*, Z. Wang*
University of Science and Technology of China, Hefei, P. R. of China
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

An Au/DNA nanohybrid (1) catalyzed the oxidative amidation of alcohols with amines in the presence of LiOH˙H2O in water under oxygen atmosphere to afford the corresponding amides in up to 96% yield (31 examples). The catalyst was recovered by centrifugation and reused four times with slight loss of its catalytic activity for the oxidative amidation of aniline with benzyl alcohol (1st reuse; 89% yield, 2nd reuse; 85% yield, 3rd reuse; 82% yield, 4th reuse; 80% yield).