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Synfacts 2011(12): 1329-1329
DOI: 10.1055/s-0031-1289386
DOI: 10.1055/s-0031-1289386
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Diastereo- and Enantioselective Direct Aldol Reactions Mediated by CoCl2/l-Proline
A. Karmakar, T. Maji, S. Wittmann, O. Reiser*
Universität Regensburg, Germany
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
Metal-amino acid combinations have proved to be highly useful in catalysis; in the context of enantioselective aldol reactions zinc-proline systems received considerable attention. In this work the CoCl2/l-proline catalyst was found to be superior to proline itself and other metal-amino acid combinations in direct aldol reactions. Cyclic and acyclic (including unsymmetrical) ketones were treated with aromatic and aliphatic aldehydes to give high yields of aldol products with high to excellent enantioselectivities and moderate to excellent dr values.