Synfacts 2011(12): 1347-1347  
DOI: 10.1055/s-0031-1289352
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Bridgehead Radicals for Coupling of Oxygenated Carbocycles

Contributor(s): Paul Knochel, Thomas Kunz
D. Urabe, H. Yamaguchi, M. Inoue*
The University of Tokyo, Japan
Further Information

Publication History

Publication Date:
18 November 2011 (online)

Significance

Herein, a radical-mediated stereoselective coupling method for the assembly of highly oxygenated carbocycles is reported. An α-alkoxy bridgehead radical is used to form linkages between tertiary alkoxy carbon atoms and tertiary or quaternary carbons. This protocol allows the assembly of complex bicyclic molecules to form the two oxygenated ring-structure substrates.