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Synfacts 2011(12): 1268-1268
DOI: 10.1055/s-0031-1289343
DOI: 10.1055/s-0031-1289343
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (+)-Gliocladin C
L. Furst, J. M. R. Narayanam, C. R. J. Stephenson*
Boston University, USA
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
Gliocladin C is a C3-C3′ indole alkaloid and is cytotoxic against P-388 lymphocytic leukemia cell lines with an ED50 value of 240 ng mL-¹. The wider hexahydropyrroloindoline alkaloid family, of which gliocladin C is a member, has gained significant synthetic interest. However, there has only been one total synthesis and two approaches to the core that have not been based on a dimeric C3-C3′ bisindole approach. The key step in this non-dimeric approach is the radical coupling mediated by visible-light photoredox catalysis.