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Synfacts 2011(12): 1281-1281  
DOI: 10.1055/s-0031-1289339
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-N-Methylwelwitindolinone C Isothiocyanate

Contributor(s): Steven V. Ley, Philippa B. Cranwell
A. D. Huters, K. W. Quasdorf, E. D. Styduhar, N. K. Garg*
University of California, Los Angeles, USA
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

The welwitindolinone class of natural products is isolated from the blue-green algae Hapalosiphon welwitschii and Westiella intricata. The target molecule was shown to reverse P-glycoprotein-mediated multiple drug resistance to a variety of cancer drugs in human cell lines. It is therefore promising as a lead for treatment of drug-resistant tumors.