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Synfacts 2011(12): 1339-1339  
DOI: 10.1055/s-0031-1289330
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed Intramolecular Asymmetric Allylic Amination

Contributor(s): Hisashi Yamamoto, Jiajing Tan
C.-W. Chien, C. Shi, C.-F Lin, I. Ojima*
Stony Brook University - State University of New York, USA
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

1-Vinyltetrahydroisoquinoline derivatives are obtained in high yields and enantioselectivities by the means of Pd-catalyzed intramolecular asymmetric allylic aminations, using MPN and BOP ligands developed in the authors’ group.

Review: For a review on allylic substitution, see: B. M. Trost, M. L. Crawley Chem. Rev. 2003, 103, 2921-2943.