Download PDF
Synfacts 2011(11): 1197-1197  
DOI: 10.1055/s-0031-1289184
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Tandem Catalytic Allylic Amination and [2,3]-Stevens Rearrangement of Tertiary Amines

Contributor(s): Hisashi Yamamoto, Susumu Oda
A. Soheili, U. K. Tambar*
The University of Texas Southwestern Medical Center at Dallas, USA
Further Information

Publication History

Publication Date:
19 October 2011 (online)

    Permissions and Reprints

Significance

The authors described the first ­example of an intermolecular allylic amination of tertiary amines and subsequent [2,3]-Stevens ­rearrangement. The tandem ammonium ylide generation/[2,3]-Stevens rearrangement gave access to a wide range of complicated amino acid derivatives with good yield and diastereoselectivity.