Abstract
Introduction:
Fitness to drive is an important prerequisite for the functional autonomy and thus
also relevant for patients with a psychiatric illness. The efficacy of sertindole
in the treatment of positive and negative schizophrenia symptoms has been shown in
various studies. However, hitherto there exist no data about patients’ fitness to
drive under sertindole.
Methods:
A non-randomized clinical study with 30 schizophrenic inpatients receiving sertindole
(n=10), risperidone (n=10) or quetiapine (n=10) was conducted. Patients were tested
under steady-state plasma level conditions prior to discharge to outpatient treatment.
Data were collected with the computerized Act and React Testsystem (ART90) and the
Wiener Determinationsgerät (WDG) measuring psychomotor skills relevant for fitness
to drive.
Results:
The main findings of this study are (i) that about 26% of schizophrenic patients,
following psychopathologic stabilization and prior discharge to outpatient treatment
show severe impairments with respect to driving skills. (ii) Statistically significant
differences between atypical antipsychotics could neither be demonstrated on the level
of the global driving ability score nor on individual functional domains essential
for fitness to drive.
Conclusion:
With respect to driving skills no differences have been found between patients treated
with sertindole, risperidone or quetiapine. However, a great proportion of schizophrenic
patients partly remitted must be considered as unfit to drive, even when stabilized
on treatment with atypical antipsychotics.
Key words
driving ability - antipsychotic drugs - schizophrenia
