Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000011.xml
Dtsch Med Wochenschr 2011; 136(10): 475-479
DOI: 10.1055/s-0031-1274530
DOI: 10.1055/s-0031-1274530
Prinzip & Perspektive | Review article
Genetik, Hämatologie© Georg Thieme Verlag KG Stuttgart · New York
Epigenetische Modifikationen in malignen Zellen
Relevanz für die Therapie von myelodysplastischem Syndrom und akuter myeloischer LeukämieEpigenetic changes in malignant cellsRelevance for the treatment of myelodysplastic syndrome and acute myeloic leukemiaFurther Information
Publication History
eingereicht: 3.12.2010
akzeptiert: 27.2.2011
Publication Date:
01 March 2011 (online)

Schlüsselwörter
Epigenetik - DNA-Methylierung - Histone
Keywords
epigenetics - DNA methylisation - histones
Literatur
- 1
Almstedt M, Blagitko-Dorfs N, Duque-Afonso J. et al .
The DNA demethylating agent 5-aza-2’-
deoxycytidine induces expression of NY-ESO-1 and other cancer/testis
antigens in myeloid leukemia cells.
Leuk Res.
2010;
34
899-905
MissingFormLabel
- 2
Borthakur G, Ahdab S E, Ravandi F. et al .
Activity of decitabine in patients with
myelodysplastic syndrome previously treated with azacitidine.
Leuk Lymphoma.
2008;
49
690-695
MissingFormLabel
- 3
Cashen A F, Schiller G J, O’Donnell M R, DiPersio J F.
Multicenter, phase II study of decitabine for the first-line
treatment of older patients with acute myeloid leukemia.
Clin
Oncol.
2010;
28
556-561
MissingFormLabel
- 4
Fenaux P, Mufti G J, Hellström-Lindberg E. et al .
Azacitidine prolongs overall
survival compared with conventional care regimens in elderly patients
with low bone marrow blast count acute myeloid leukemia.
J
Clin Oncol.
2010;
28
562-569
MissingFormLabel
- 5
Fenaux P, Mufti G J, Hellström-Lindberg E. et al .
Efficacy of azacitidine compared
with that of conventional care regimens in the treatment of higher-risk
myelodysplastic syndromes: a randomised, open-label, phase III study.
Lancet Oncol.
2009;
10
223-232
MissingFormLabel
- 6
Field T, Perkins J, Huang Y. et
al .
5-Azacitidine for myelodysplasia before allogeneic
hematopoietic cell transplantation.
Bone Marrow Transplant.
2010;
45
255-260
MissingFormLabel
- 7
Flotho C, Claus R, Batz C. et
al .
The DNA methyltransferase inhibitors azacitidine,
Decitabine and zebularine exert differential effects on cancer gene
expression in acute myeloid leukemia cells.
Leukemia.
2009;
23
1019-1028
MissingFormLabel
- 8
Garcia-Manero G, Yang H, Bueso-Ramos C. et al .
Phase 1 study of the histone deacetylase
inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA])
in patients with advanced leukemias and myelodysplastic syndromes.
Blood.
2008;
111
1060-1066
MissingFormLabel
- 9
Goodyear O, Agathanggelou A, Novitzky-Basso I. et al .
Induction of a CD8+ T-cell
response to the MAGE cancer testis antigen by combined treatment
with azacitidine and sodium valproate in patients with acute myeloid
leukemia and myelodysplasia.
Blood.
2010;
116
1908-1918
MissingFormLabel
- 10
Hackanson B, Guo Y, Lübbert M.
The silence of the genes: epigenetic disturbances in haematopoietic
malignancies.
Expert Opin Ther Targets.
2005;
9
45-61
MissingFormLabel
- 11
Issa J-P J, Kantarjian H M.
Targeting
DNA methylation.
Clin Cancer Res.
2009;
15
3938-3946
MissingFormLabel
- 12
Kantarjian H, Issa J P, Rosenfeld C S. et al .
Decitabine improves patient outcomes
in myelodysplastic syndromes: results of a phase III randomized
study.
Cancer.
2006;
106
1794-1803
MissingFormLabel
- 13
Kornblith A B, Herndon 2nd J E, Silverman L R. et al .
Impact of azacytidine on the quality of life of patients with
myelodysplastic syndrome treated in a randomized phase III trial:
a Cancer and Leukemia Group B study.
J Clin Oncol.
2002;
20
2441-2452
MissingFormLabel
- 14
Kuendgen A, Schmid M, Schlenk R. et al .
The histone deacetylase (HDAC) inhibitor
valproic acid as monotherapy or in combination with all-trans retinoic
acid in patients with acute myeloid leukemia.
Cancer.
2006;
106
112-119
MissingFormLabel
- 15
Ley T J, Ding L, Walter M J. et al .
DNMT3A mutations in acute myeloid leukemia.
N Engl J Med.
2010;
363
2424-2433
MissingFormLabel
- 16
Lübbert M, Bertz H, Rüter B. et al .
Non-intensive treatment with low-dose 5-aza-2’-
deoxycytidine (DAC) prior to allogeneic blood SCT of older MDS/AML
patients.
Bone Marrow Transplant.
2009;
44
585-588
MissingFormLabel
- 17
Lübbert M, Suciu S, Baila L. et
al .
Low-dose decitabine vs. best supportive care in
elderly patients with intermediate- or high-risk MDS ineligible
for intensive chemotherapy: final results of the randomized phase
III study of the EORTC Leukemia Group and the German MDS Study Group.
J Clin Oncol.
in press 2011
MissingFormLabel
- 18
Marcucci G, Haferlach T, Döhner H.
Molecular genetics of adult acute myeloid leukemia: prognostic
and therapeutic implications.
J Clin Oncol.
2011;
29
475-486
MissingFormLabel
- 19
Möller I, Blum S, Gattermann N at
al.
Repeated responses of an elderly patient with
high-risk myelodysplastic syndrome to sequential therapy with tipifarnib,
5-azacitidine, and decitabine.
Ann Hematol.
2009;
88
1141-1144
MissingFormLabel
- 20
Silverman L R, Demakos E P, Peterson B L. et al .
Randomized controlled trial
of azacitidine in patients with the myelodysplastic syndrome: a study
of the cancer and leukemia group B.
J Clin Oncol.
2002;
20
2429-2440
MissingFormLabel
- 21
Wagner J, Hackanson B, Lübbert M. et al .
Histone deacetylase (HDAC) inhibitors in
recent clinical trials for cancer therapy.
Clin Epigenet.
2010;
1
117-136
MissingFormLabel
Dr. med. Björn Hackanson
Medizinische Universitätsklinik Freiburg
Abteilung
Hämatologie und Onkologie
Hugstetter
Str. 55
79106 Freiburg
Phone: 0761/2707715
Email: bjoern.hackanson@uniklinik-freiburg.de