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Synlett 2011(18): 2605-2608
DOI: 10.1055/s-0030-1289521
DOI: 10.1055/s-0030-1289521
SYNPACTS
© Georg Thieme Verlag
Stuttgart ˙ New YorkSynthetic Strategies toward the Guaiane Sesquiterpene Englerin A
Weitere Informationen
Received
10 August 2011
Publikationsdatum:
06. Oktober 2011 (online)
Publikationsverlauf
Publikationsdatum:
06. Oktober 2011 (online)
Abstract
Englerin A is a guaiane sesquiterpene with potent and selective growth inhibition activity against six human renal cancer cell lines. Since the disclosure of its structure in 2009, englerin A has been the subject of intense study by the synthetic organic chemistry community, and several elegant strategies have been developed for the total synthesis of this exciting natural product. These strategies are discussed herein.
Key words
terpenoids - total synthesis - antitumor agents - natural products - carbonyl
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