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Synthesis 2011(18): 2907-2912  
DOI: 10.1055/s-0030-1261030
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Copper(I) Iodide Catalyzed Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from anti-3-Aryl-2,3-dibromopropanoic Acids and Organic Azides

Xuezhi Chenga, Yiwen Yanga, Chunxiang Kuang*a, Qing Yang*b
a Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China
Fax: +86(21)65983191; e-Mail: kuangcx@tongji.edu.cn;
b Department of Biochemistry, School of Life Sciences, Fudan University, Handan Road 220, Shanghai 200433, P. R. of China
e-Mail: yangqing68@fudan.edu.cn;
Further Information

Publication History

Received 30 May 2011
Publication Date:
05 August 2011 (online)

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Abstract

A series of 1,4-disubstituted 1,2,3-triazoles were synthesized in a one-pot process from anti-3-aryl-2,3-dibromopropanoic acids and organic azides in dimethyl sulfoxide with inexpensive copper (I) iodide as the catalyst.

Key words

cyclizations - heterocycles - azides - triazoles

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