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Synlett 2011(14): 2029-2034
DOI: 10.1055/s-0030-1260978
DOI: 10.1055/s-0030-1260978
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
An Oxidant-Free Single-Step Synthesis of Tetra- or Disubstituted Symmetrical Pyridine Derivatives by a Hf(OTf)4-Catalyzed Annulation
Further Information
Received
5 January 2011
Publication Date:
03 August 2011 (online)
Publication History
Publication Date:
03 August 2011 (online)

Abstract
The Hf(OTf)4-catalyzed unprecedented annulation of an enamine with triethyl orthoformate leading to the preparation of tetrasubstituted symmetrical pyridine derivatives without an oxidant is described. This method accommodated the single-step synthesis of a disubstituted symmetrical pyridine using an acetophenone derivative, triethyl orthoformate, and ammonium acetate (NH4OAc).
Key words
heterocycles - pyridines - hafnium triflate - enamines - orthoesters
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