Synthesis of Novel 2-Cyano-7-deaza-8-azapurine-
and 2-Cyano-8-azapurine-Derived Nucleosides

Philip Wainwright; Adrian Maddaford; Michael Simms; Neil Forrest; Rebecca Glen; James Hart; Xiurong Zhang; David C. Pryde; Peter T. Stephenson; Donald S. Middleton; Thierry Guyot; Scott C. Sutton

doi:10.1055/s-0030-1260943

LETTER

Synthesis of Novel 2-Cyano-7-deaza-8-azapurine- and 2-Cyano-8-azapurine-Derived Nucleosides

Philip Wainwright*^a, Adrian Maddaford^a, Michael Simms^a, Neil Forrest^a, Rebecca Glen^a, James Hart^a, Xiurong Zhang^a, David C. Pryde^b, Peter T. Stephenson^b, Donald S. Middleton^b, Thierry Guyot^b, Scott C. Sutton^c
^a Peakdale Molecular Ltd., Peakdale Science Park, Sheffield Road, Chapel-en-le-frith, High Peak, SK23 0PG, UK
Fax: +44(1298)816701; e-Mail: phil.wainwright@peakdale.co.uk;
^b Discovery Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, CT13 9NJ, UK
^c Pfizer Global Research and Development, 10770 Science Centre Drive, San Diego, CA 92121, USA

Abstract

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Abstract

A novel systematic approach to the synthesis of 2-cyano-7-deaza-8-azapurine derived nucleosides is described. It is shown how this chemistry was developed with the labile 2-substituted nitrile position in mind, and also how the same approach is applicable to 2-cyano-8-azapurine derived nucleosides.

Key words

nucleosides - nitriles - protecting groups - heterocycles - glycosylation

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References

References and Notes

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