Synthesis of Pyrimidin-4(3H)-ones
via Vilsmeier-Haack Reaction

doi:10.1055/s-0030-1260511

RSS-Feed abonnieren

Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.

https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml

Teilen / Bookmarken

Facebook Linkedin Weibo

PDF herunterladen

Synfacts 2011(7): 0714-0714
DOI: 10.1055/s-0030-1260511

Synthesis of Heterocycles

Synthesis of Pyrimidin-4(3H)-ones via Vilsmeier-Haack Reaction

Contributor(s): Victor Snieckus, Yigang Zhao
R. Zhang, D. Zhang, Y. Liang, G. Zhou, D. Dong*
Changchun Institute of Applied Chemistry, P. R. of China

Weitere Informationen

Publikationsverlauf

Publikationsdatum:
17. Juni 2011 (online)

Lizenzen und Reprints

Significance

Described is a one-pot efficient synthesis of pyrimidin-4(3H)-ones 2 via Vilsmeier-Haack reaction of readily available aminopropenamides 1. This process is proposed to involve a halogenation, formylation, and intramolecular nucleophilic cyclization sequence. The reaction scope and limitations were not well investigated.