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Synthesis 2011(23): 3887-3893  
DOI: 10.1055/s-0030-1260258
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Vitamin D Heterocyclic Analogues; Part 2: Synthesis of the First Vitamin D Analogues with a Tetrazole Ring at the Side Chain

Zoila Gándara, Pedro Lois Suárez, Maria González, Generosa Gómez*, Yagamare Fall*
Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain
Fax: +34(98)6812262; e-Mail: yagamare@uvigo.es; e-Mail: ggomez@uvigo.es;
Further Information

Publication History

Received 2 August 2011
Publication Date:
07 October 2011 (online)

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Abstract

Access to the calcitriol analogues with a tetrazole ring at the side chain was very efficiently achieved using the Calverley-Choudhry approach instead of the Wittig-Horner method, which gave very low yields.

Key words

1α,25-dihydroxyvitamin D3 - tetrazole - heterocycles - azasteroids - Windhaus-Grundmann ketone

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