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Synthesis 2011(19): 3123-3132
DOI: 10.1055/s-0030-1260187
DOI: 10.1055/s-0030-1260187
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkAsymmetric Induction by (S)-4-Isopropyl-1-phenylimidazolidin-2-thione in Titanium-Mediated Aldol Reactions and Its Application in Enantioselective Synthesis of (R)-Baclofen
Further Information
Received
25 May 2011
Publication Date:
24 August 2011 (online)
Publication History
Publication Date:
24 August 2011 (online)

Abstract
The usefulness of (S)-4-isopropyl-1-phenylimidazolidin-2-thione as a chiral auxiliary in stereoselective propionate and acetate aldol reactions is discussed. Further, the enantioselective synthesis of (R)-baclofen by acetate aldol reaction using the chiral auxiliary was demonstrated.
Key words
titanium - aldol reaction - asymmetric synthesis - chiral auxiliaries - stereoselectivity
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