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Synthesis 2011(17): 2721-2723  
DOI: 10.1055/s-0030-1260160
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

Convenient Laboratory Method for the Synthesis of Symmetrical 1,3-Diphenylacetone Derivatives

Duane R. Romer
The Dow Chemical Company, Core R&D, 1776 Building, Midland, MI 48674, USA
e-Mail: drromer2@dow.com;
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Publication History

Received 27 May 2011
Publication Date:
08 August 2011 (online)

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Abstract

A practical one-pot, two-step procedure for the synthesis of symmetrical 1,3-diphenylacetone derivatives from the corresponding phenylacetate has been developed. This procedure has been demonstrated by the synthesis of 1,3-diphenylacetone at the >50-gram scale in >99% purity.

Key words

condensation - ketones - esters - addition - aldol reaction

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