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Synthesis 2011(16): 2644-2650
DOI: 10.1055/s-0030-1260099
DOI: 10.1055/s-0030-1260099
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkFacile Synthesis of Pyrimidine-Isoxazoline Hybrids in a [bmim][PF6]-Water Biphasic System
Further Information
Received
25 March 2011
Publication Date:
27 July 2011 (online)
Publication History
Publication Date:
27 July 2011 (online)
Abstract
The convenient synthesis of a library of pyrimidine-isoxazoline hybrids in 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6])-water/potassium hydroxide at ambient temperature has been accomplished. The ionic liquid [bmim][PF6], immiscible in water, can be easily recycled for reuse after separation of the products without any noticeable diminution in its activity. The protocol is rapid, the yields are good to excellent, and the method is facile.
Key words
pyrimidines - dihydroisoxazoles - ionic liquids - water - biphasic systems
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