A Facile Synthesis of 6H-[1,3,5]Triazino[2,1-b]quinazolin-6-ones

Abstract

Triazinoquinazolinone derivatives are synthesized by cyclization of aminobenzamide-substituted triazine compounds in the presence of a proton source such as trifluoroacetic acid or hydrochloric acid. The reaction is mild, general, and gives high yield (>90%) of the cyclized product. This procedure allows, for the first time, access to triazinoquinazolinone compounds bearing different functionalities on the benzene and triazine moieties that are not available by other routes.

Key words

amides - heterocycles - cyclization - carboxylic acids - esters

References

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