Abstract
Ethylene and propylene carbonates are shown to be alternative
polar aprotic solvents for cross-aldol reactions catalysed by the
primary amino acids (S )-phenylalanine
and (S )-tryptophan. In contrast to the
corresponding proline-catalysed reactions, both enantiomers of these
naturally occurring, primary amino acids are available at low cost.
The optimal catalyst and solvent combination needs to be determined
on a substrate by substrate basis.
Key words
aldol reaction - amino acids - asymmetric catalysis - green chemistry - cyclic carbonate
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