Download PDF
Synfacts 2011(5): 0538-0538  
DOI: 10.1055/s-0030-1259773
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Cross-Coupling of Benzazoles with Azoles

Contributor(s): Paul Knochel, Thomas Kunz
W. Han, P. Mayer, A. R. Ofial*
Ludwig-Maximilians-Universität München, Germany
Further Information

Publication History

Publication Date:
15 April 2011 (online)

    Permissions and Reprints

Significance

The authors report a palladium-­catalyzed cross-coupling of benzazoles with azoles containing N, O, and S atoms. This efficient procedure is mediated by Cu(II), Ag(I), and acetate ions and can be carried out under air atmosphere. The bisheteroaryl compounds are obtained by a selective C-C bond formation at the C2 positions without the necessity of preactivation of every C-H bond.