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Synfacts 2011(4): 0419-0419
DOI: 10.1055/s-0030-1259665
DOI: 10.1055/s-0030-1259665
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Iridium-Catalyzed Asymmetric Intramolecular Allylic Amidation
J. F. Teichert, M. Fañanás-Mastral, B. L. Feringa*
University of Groningen, The Netherlands
Further Information
Publication History
Publication Date:
18 March 2011 (online)
Significance
In this paper, a highly efficient protocol for iridium-catalyzed enantioselective intramolecular allylic amidation reaction was developed. The desired tetrahydroisoquinoline derivatives as well as other saturated nitrogen-containing heterocycles were obtained with excellent enantioselectivities.