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Synfacts 2011(4): 0384-0384  
DOI: 10.1055/s-0030-1259625
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

New Precursor for Difluorocarbenes

Contributor(s): Timothy M. Swager, Shuang Liu
F. Wang, W. Zhang, J. Zhu, H. Li, K.-W. Huang*, J. Hu*
Shanghai Institute of Organic Chemistry, P. R. of China and King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

Developing new fluorination methods is of great interest in areas such as material science and pharmaceuticals. However, the existing fluoroalkylation reagents are usually generated from hazardous materials or under harsh conditions. The authors demonstrated that (chlorodi­fluoromethyl)trimethylsilane (TMSCF2Cl) can be used as the precursor for difluorocarbene (:CF2) under neutral and relatively mild conditions.