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Synfacts 2011(3): 0308-0308
DOI: 10.1055/s-0030-1259415
DOI: 10.1055/s-0030-1259415
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Selective Palladium-Catalyzed Oxidation of Glycerol to Dihydroxyacetone
R. M. Painter, D. M. Pearson, R. M. Waymouth*
Stanford University, USA
Further Information
Publication History
Publication Date:
16 February 2011 (online)
Significance
A dimeric phenanthroline-based palladium acetate complex catalyzes the chemoselective oxidative transformation of glycerol into dihydroxyacetone. Both benzoquinone and air are effective oxidants and the reaction proceeds readily on a 10 mmol scale in wet acetonitrile or DMSO as solvents.