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Synfacts 2011(2): 0198-0198  
DOI: 10.1055/s-0030-1259245
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Control of Product Selectivity in Ruthenium-Catalyzed C-H Arylation

Contributor(s): Paul Knochel, Andreas J. Wagner
S. Hiroshima, D. Matsumura, T. Kochi, F. Kakiuchi*
Keio University, Yokohama, Japan
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Publication History

Publication Date:
19 January 2011 (online)

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Significance

The presence of styrene as additive in the ruthenium-catalyzed C-H arylation of aceto-phenones is shown to have a unique effect on product selectivity. While the reaction gives predominantly diarylation products, the addition of stoichiometric amounts of styrene switches the product selectivity and favors the formation of the monoarylated product.