Iridium-Catalyzed ortho-Silylation
of Arenes by Hydroxyl-Directed C-H Activation

E. M. Simmons; J. F. Hartwig

doi:10.1055/s-0030-1259244

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Synfacts 2011(2): 0205-0205
DOI: 10.1055/s-0030-1259244

Metal-Mediated Synthesis

Iridium-Catalyzed ortho-Silylation of Arenes by Hydroxyl-Directed C-H Activation

Contributor(s): Paul Knochel, Andreas J. Wagner
E. M. Simmons, J. F. Hartwig*
University of Illinois, Urbana, USA

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Publication History

Publication Date:
19 January 2011 (online)

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Significance

A hydroxyl group serves as the directing element for iridium-catalyzed C-H bond activation via dehydrogenative cyclization of in situ generated diethyl(hydrido)silyl ethers. A range of functional groups were found to be compatible with the reaction conditions.