Synfacts 2011(2): 0202-0202  
DOI: 10.1055/s-0030-1259237
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Cyanation of Aryl Mesylates

Contributor(s): Paul Knochel, Thomas Kunz
P. Y. Yeung, C. M. So, C. P. Lau, F. Y. Kwong*
The Hong Kong Polytechnic University, P. R. of China
Further Information

Publication History

Publication Date:
19 January 2011 (online)

Significance

The first general palladium-catalyzed cyanation of aryl mesylates and tosylates is disclosed. The reaction proceeds under very mild conditions and tolerates functional groups, such as esters, ketones, and aldehydes. The use of ­water as solvent or co-solvent was found to be essential.