Pyrrole Acylation for the Synthesis
of 2-Bromo-6-(2-pyrrolyl)pyridine and Subsequent Cross-Coupling
Reactions

Chuanjun Song; Yan Liu; Peng Zhao; Xuelian Sun; Wenjia Li; Hui Liu; Junbiao Chang

doi:10.1055/s-0030-1258971

PAPER

Pyrrole Acylation for the Synthesis of 2-Bromo-6-(2-pyrrolyl)pyridine and Subsequent Cross-Coupling Reactions

Chuanjun Song*^a, Yan Liu^a, Peng Zhao^a, Xuelian Sun^b, Wenjia Li^a, Hui Liu^a, Junbiao Chang*^a
^a Department of Chemistry, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan Province 450001, P. R. of China
e-Mail: chjsong@zzu.edu.cn; e-Mail: changjunbiao@zzu.edu.cn;
^b School of International Education, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan Province 450001, P. R. of China

Abstract

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Abstract

A facile synthesis of 2-bromo-6-pyrrolylpyridine 4 was developed starting from acylation of pyrrole with glutaric acid and TFAA. Suzuki cross-couplings of 4 with arylboronic acids gave a variety of novel 2-aryl-6-pyrrolylpyridines in excellent yields.

Key words

pyrrole acylation - 2-bromo-6-pyrrolylpyridine - 2-aryl-6-pyrrolylpyridines - Suzuki cross-coupling - detosylation

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