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Synthesis 2011(1): 45-50
DOI: 10.1055/s-0030-1258971
DOI: 10.1055/s-0030-1258971
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkPyrrole Acylation for the Synthesis of 2-Bromo-6-(2-pyrrolyl)pyridine and Subsequent Cross-Coupling Reactions
Further Information
Received
21 September 2010
Publication Date:
09 November 2010 (online)
Publication History
Publication Date:
09 November 2010 (online)
Abstract
A facile synthesis of 2-bromo-6-pyrrolylpyridine 4 was developed starting from acylation of pyrrole with glutaric acid and TFAA. Suzuki cross-couplings of 4 with arylboronic acids gave a variety of novel 2-aryl-6-pyrrolylpyridines in excellent yields.
Key words
pyrrole acylation - 2-bromo-6-pyrrolylpyridine - 2-aryl-6-pyrrolylpyridines - Suzuki cross-coupling - detosylation
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