Organocatalytic Corey-Chaykovsky Reaction of Ketones

S. A. Kavanagh; A. Piccinini; S. J. Connon

doi:10.1055/s-0030-1258931

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Synfacts 2010(12): 1418-1418
DOI: 10.1055/s-0030-1258931

Organo- and Biocatalysis

Organocatalytic Corey-Chaykovsky Reaction of Ketones

Contributor(s): Benjamin List, Lars Ratjen
S. A. Kavanagh, A. Piccinini, S. J. Connon*
University of Dublin, Ireland

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Publication History

Publication Date:
22 November 2010 (online)

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Significance

The authors report the metal-free, catalytic Corey-Chaykovsky reaction of ketones. The catalyst system, sulfide 1 in combination with P₂-phosphazene base, proton sponge, and MeOTf as methylene source, delivered various aromatic and aliphatic epoxide products in high yields.