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Synfacts 2010(12): 1442-1442  
DOI: 10.1055/s-0030-1258919
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric C-H Insertion with a Polymer-Supported Rhodium Complex

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
K. Takeda, T. Oohara, M. Anada, H. Nambu, S. Hashimoto*
Hokkaido University, Sapporo, Japan
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Publication History

Publication Date:
22 November 2010 (online)

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Significance

Polymer-supported chiral dirhodium(II) complex 4 was prepared by copolymerization of complex 2 with 1 and 3 (eq. 1). Complex 4 catalyzed the asymmetric intramolecular C-H insertion of diazo esters (5, 7, and 9) to give the corresponding cyclic compounds (6, 8, and 10) in 83-86% yield with 91-94% ee (eqs. 2-4).