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DOI: 10.1055/s-0030-1258910
A Flow Reaction System Using Catalytic Magnetic Particles
Contributor(s):Yasuhiro Uozumi, Yoichi M. A. Yamada, Maki MinakawaChungnam National University, Daejeon, South Korea
A Microchemical System with Continuous Recovery and Recirculation of Catalyst-Immobilized Magnetic Particles
Angew. Chem. Int. Ed. 2010, 49: 6825-6829
Publication History
Publication Date:
22 November 2010 (online)
Key words
magnetic particles - microseparator chip - capillary microtubes - flow chemistry
Significance
A novel fluidic system using catalytic magnetic particles was developed. In the separator part (microseparator), the product stream with the catalytic magnetic particles merged with the solvent stream, and the particles in the product stream moved into the solvent stream with the aid of the external magnetic field. Almost no mixing and thus, almost complete separation occurred as a result of laminar flow. The dioxygenation of alkenes was carried out in the fluidic system using catalyst particle 1 (4 examples, 83-89% yield).
Comment
The flow system consists of a microfluidic chip type of a microseparator [poly(dimethylsiloxane): width: 300 µm, depth: 50 µm, length: 20 mm] and a capillary microtube reactor [poly-(tetrafluoroethylene): diameter: 500 µm, length: 260 cm]. In the preparation of magnetic catalyst 1, commercially available magnetic particles having silica surface functionalized with primary amine groups were used (average size: 1.99 mm, AccuBead, bioneer, Korea).