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Synfacts 2010(12): 1399-1399
DOI: 10.1055/s-0030-1258897
DOI: 10.1055/s-0030-1258897
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New YorkRuthenium-Catalyzed Asymmetric Reduction of α-Keto Acids
L. Zhu, Q. Meng, W. Fan, X. Xie, Z. Zhang*
Nanjing University of Science & Technology, Shanghai Jiao Tong University and Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History
Publication Date:
22 November 2010 (online)
Significance
The authors describe the first effective method for the asymmetric reduction of unsaturated α-keto acids, which are easily obtained by condensation of an aldehyde with pyruvic acid. These substrates are particularly challenging due to complexation of the substrate or product with the catalyst.