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Synfacts 2010(12): 1390-1390  
DOI: 10.1055/s-0030-1258892
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Asymmetric Hydro-formylation

Contributor(s): Mark Lautens, Jane Panteleev
R. I. McDonald, G. W. Wong, R. P. Neupane, S. S. Stahl*, C. R. Landis*
University of Wisconsin-Madison, USA
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Publikationsdatum:
22. November 2010 (online)

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Significance

Over the past decade, the Landis group has contributed consistently to the development of enantioselective rhodium-catalyzed ­hydroformylation (see Review below). The authors expand on their earlier work by applying the rhodium BisDiazaphos catalyst to vinyl carboxamides, allyl ethers, and allyl carbamates. The catalyst loading is low and an application of this strategy is demonstrated in the synthesis of the Roche aldehyde.

Review: J. Klosin, C. R. Landis. Acc. Chem. Res. 2007, 40, 1251-1259.