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Synfacts 2010(12): 1333-1333  
DOI: 10.1055/s-0030-1258880
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Total Synthesis of Chloptosin

Contributor(s): Steven V. Ley, Catherine F. Carter
A. J. Oelke, D. J. France, T. Hofmann, G. Wuitschik, S. V. Ley*
University of Cambridge, UK
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Publikationsdatum:
22. November 2010 (online)

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Significance

Chloptosin was isolated from a ­culture broth of Streptomyces by Umezawa et al. It induces apoptosis in several apoptosis-sensitive cancer cell lines and displays antimicrobial activity.